67 research outputs found

    Interchange 61 : providing drug education to meet young people's needs

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    WP3 Policy Mapping, Review and Analysis

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    This report presents the mapping, review and analysis of the most relevant LLL policies for young adults in Glasgow City Region and Aberdeen/ Aberdeenshire. The report first reviews the national Scottish LLL policies which influence the implementation of LLL for young adults in the two regions under study. This report provides findings and analysis to comply with the H2020 YOUNG_ADULLLT Research Project, Work Package 3 (WP3). We have used the requirements and guidance in the WP3 proposal to select two appropriate Functional Regions (FRs): The Glasgow City Region and Aberdeen/Aberdeenshire. These FRs provide a focus for the WP3 mapping but also frame the other data gathering for the YOUNG_ADULLLT project. The mapping has provided material to facilitate an understanding of the policy landscape, including the different policy sectors of the two FRs set in the national context. The mapping required the selection of three detailed examples of LLL/Skills policies with their associated material actions in each of the two FRs. Currently, we have mapped four in each FR. Our mapping reflects the distinctiveness of Scottish public policy in that national policies provide the main framework for regional and locally devolved enactment and associated actions

    Production of case studies of the delivery of skills for learning, skills for life and skills for work

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    This report summarises the main themes to emerge from a study to highlight good practice in delivering practical, applied or vocational learning provision for all pupils

    Oxford nanopore sequencing enables rapid discovery of single-domain antibodies from phage display libraries.

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    Antibody (Ab) repertoire sequencing using high-throughput massively parallel technologies has contributed substantially to the understanding of Ab responses following infection, vaccination and autoimmunity. Because individual B-cell receptors are recombined and diversified somatically, genomic comparisons are limited, and distinguishing rare variants from sequencing errors is a major challenge. Oxford Nanopore Technologies' MinION is a highly portable and cost-effective third-generation sequencing instrument, but has not been used for Ab repertoire sequencing due to its high error rate (approximately 1/10 bases). Here, we applied nanopore sequencing to single-domain Ab (sdAb) repertoires and phage-displayed sdAb libraries. We show that despite low overall data fidelity, sdAb sequences could be reconstructed above a frequency threshold (∼100 copies); however, distinguishing clonal sdAb variants was not always possible. The data quality was sufficient to enable rapid identification of antigen-specific sdAb sequences enriched during panning of phage display libraries, obviating the need for screening single clones
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